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Abstract
Violation of the functional state of the vascular endothelium to this day not lost its relevance, given the wide range of pathophysiological mechanisms that underlie the violations of the functional state of the vascular endothelium. Тhe aim of our study is to identify vascular endothelial dysfunction in patients with peptic ulcer of stomach and duodenal ulcers combined with arterial hypertension and diabetes mellitus type 2, by investigation of disorders of the quantitative indicator of desquamating endothelial cells (DEC), changes in the content of ET-1, levels of nitrate/nitrite, and adhesion molecules (sVCAM-1) and to assess their condition after treatment. The direct influence of Helicobacter pylori, and especially strains it violates the condition of the vascular endothelium, metabolic exchange and stimulates the development of markers of inflammation, which are factors in the development of diclophenac, hypertension and atherosclerosis. In turn, the violation of the synthesis of ET-1 as a potent vasoconstrictor that regulates angiogenesis, sudio, leads to an increase of its release. At the same time, changes in the vascular endothelium is accompanied by the increasing in the number of desquamating endothelial cells and vascular adhesion molecules sVCAM 1, which indicate the early development of atherosclerosis in hypertension, coronary heart disease, diabetes type 2, atherosclerosis of cerebral and peripheral vessels, and the like. A lot of research attention is paid to risk factors of endothelial dysfunction (DE): arterial hypertension (AH), hypercholesterolemia, diabetes, lead to damage of the endothelium of blood vessels, (changes in the content of nitrates/ nitrites, ET-1, sVCAM-1 in the blood). The use of combined probiotic “Latium“ leads to the improvement of the endothelium by providing the acidic pH of the medium, suppression of growth of pathogenic and conditionally pathogenic bacteria, contributes to the action of digestive enzymes.